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Once expanded, the hydrogel remains soft and compliant.
The hydrogel is an inert substance that:

  • Does not contain or produce biologics
  • Is not associated with any known toxicity, in-vivo material hypersensitivity, or interaction with other embolic agents
  • Will not degrade or break down

AZUR’s unique overcoil (detachable system only) is designed to enhance trackability, deliverability, and repositioning ability.

Unexpanded hydrogel.
Magnified image of unexpanded hydrogel showing porous structure.

Expanded hydrogel.
Magnified image of expanded hydrogel. Expanded porous hydrogel provides excellent substrate for healing (neointima formation, smooth muscle cell migration).4,9,10

Endothelial formation.
This image illustrates the growth of neointima at the neck of an aneurysm in a rabbit model. Hydrogel facilitates this process.

Expanding in the direction of least resistance.
As this image illustrates, hydrogel expands in the direction of the flow – not in the direction of the vessel below.

 

References:
1. Sluzewski M, van Rooij WJ, Slob MJ, Bescós JO, Slump CH, Wijnalda D. Relation between aneurysm volume, packing, and compaction in 145 cerebral aneurysms treated with coils. Radiology. 2004;231(3):653-658.
2. Cloft HJ, Kallmes DF. Aneurysm packing with HydroCoil Embolic System versus platinum coils: initial clinical experience. AJNR Am J Neuroradiol. 2004;25(1):60-62.
3. DURABLE Multi-center HES Registry (Albany Medical Center, Beaumont Regional Medical Center, Loyola University Medical Center) of 260 aneurysms with 186 follow-ups treated with HydroCoil. Presented at ABC/WIN. 2006.
4. Plenk H, Killer M, Richling B. Pathophysiologic considerations on HydroCoil- and platinum coil-occluded retrieved human cerebral aneurysms. Presented at ASITN MicroVention Symposium. 2005.
5. Fujiwara NH, Kallmes DF. Healing response in elastase-induced rabbit aneurysms after embolization with a new platinum coil system. AJNR Am J Neuroradiol. 2002;23(7):1137-1144.
6. Kallmes DF, Fujiwara NH. New expandable hydrogel-platinum coil hybrid device for aneurysm embolization. AJNR Am J Neuroradiol. 2002;23(9):1580-1588.
7. Bavinzski G, Talazoglu V, Killer M, et al. Gross and microscopic histopathological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg. 1999;91(2):284-293.
8. HEAL Registry. MicroVention, Inc. (197 aneurysms; 128 follow-up cases; mean follow-up of 14 months).
9. Virmani R. Healing and inflammation in experimental and clinical aneurysms. Presented at WFITN. 2005.
10. Ding YH, Dai D, Lewis DA, Cloft HJ, Kallmes DF. Angiographic and histologic analysis of experimental aneurysms embolized with platinum coils, Matrix, and HydroCoil. AJNR Am J Neuroradiol. 2005;26(7):1757-1763.
11. Bui JT, West DL, Pai R, Owens CA. Use of a hydrogel-coated self-expandable coil to salvage a failed transcatheter embolization of a mesenteric hemorrhage. Cardiovasc Intervent Radiol. 2006;29(6):1121-1124.
12. Aina R, Oliva VL, Therasse E, et al. Arterial embolotherapy for upper gastrointestinal hemorrhage: outcome assessment. J Vasc Interv Radiol. 2001;12(2):195-200.
13. Fanning NF, Berentai Z, Brennan PR, Thornton J. HydroCoil as an adjuvant to bare platinum coil treatment of 100 cerebral aneurysms. Neuroradiology. 2007;49(2):139-148. Epub 2006 Nov 22.

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